Therapeutic Potential of Kappa Opioid Agonists
نویسندگان
چکیده
منابع مشابه
Docking Studies of Kappa Opioid Receptor Agonists
The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...
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Salvinorin A is the major active ingredient of Salvia divinorum, a plant used by the Mazatec Indians of Mexico for spiritual and medical purposes. Different preparations from S. divinorum are also used in traditional healing practices to treat gastrointestinal disorders, including diarrhea. The recent extensive research on salvinorin A and other neoclerodane diterpenoids derived from S. divinor...
متن کاملEffects of preferential delta and kappa opioid receptor agonists on the intake of hypotonic saline.
A previous study has implicated central mu opioid receptors in the preference for salt solutions. Because mu, kappa and delta receptors are all thought to play a role in food intake and/or the mediation of palatability, we performed a series of experiments to determine whether preferential agonists at kappa and delta receptors might also stimulate the intake of salt solutions. When injected cen...
متن کاملEvaluation of delayed treatment of focal cerebral ischemia with three selective kappa-opioid agonists in cats.
BACKGROUND AND PURPOSE The purpose of this study was to determine the therapeutic efficacy of three kappa-opioid agonists used for delayed treatment of experimental focal cerebral ischemia. METHODS Forty halothane-anesthetized cats underwent permanent occlusion of the right intracranial internal carotid, middle cerebral, and anterior cerebral arteries via a transorbital, microsurgical approac...
متن کاملAgonists and antagonists bind to different domains of the cloned kappa opioid receptor.
Opium and its derivatives are potent analgesics that can also induce severe side effects, including respiratory depression and addiction. Opioids exert their diverse physiological effects through specific membrane-bound receptors. Three major types of opioid receptors have been described, termed delta, kappa, and mu. The recent molecular cloning of these receptor types opens up the possibility ...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2019
ISSN: 1424-8247
DOI: 10.3390/ph12020095